This increases oxygenated hemoglobin at the site and removes cytokine enzymes and cellular waste. The result is more rapid healing and reduced pain. The sam® device was developed out of research funded by the National Institute of Health and US Department of Defense to accelerate soft tissue healing and reduce the use of pharmaceuticals. sam® is clinically validated in over 30 studies and has treated more than 300,000 patients successfully. Safe, Effective and Proven